Abstract: Genomatix has been at the forefront of genomics, from microarrays to next generation sequencing applications [A Global View of Gene Activity and Alternative Splicing by Deep Sequencing of the Human Transcriptome, Science 321, 956 (2008); Sultan, et al]. Its innovative data analysis software and thoroughly annotated genome databases are used by research scientists worldwide to study links between genomic information and diseases. The cost of whole-genome sequencing is going down at an accelerated pace, and many new genomics applications are now enabled. Clinical Genomics is certainly one of the most promising applications that can be envisioned, with the ability to use high throughput sequencing for the study of human genetics in the context of clinical studies. We will review how sequencing data can be analyzed to allow clinical studies, what the current challenges are, and the costs involved.

Abstract: The nearshore fish community was sampled in western Lake Erie in 2005, the lower Detroit River in 2006 and 2008, and the St. Clair Flats in 2007. A combination of electrofishing, fyke netting, and beach seines were used to target a variety of habitat types in the nearshore waters. The combined catch included 66 species of fish from 19 families. This survey documents the great variety of fish species that rely on nearshore habitat in this system for at least some stage of their life cycle. Nearshore habitat has been shown to be particularly important for juvenile game fish and forage fish production. The completion of this study provides important baseline data on the fish community in the Huron-Erie Corridor.

Abstract: Closed-loop Supply Chain Management is one of the most important concepts to realize a sustainable economy. Thereby the con guration of procurement networks for secondary raw materials is a key factor. The underlying decision problem can be classi ed as a SNP integrating a continuous location search and a technology selection. The presented framework suggests a structured procedure including a hybrid system. Thereby the hybrid system optimizes the con guration by combining a CPLEX solved MIP-Formulation with a heuristic local search approach. The framework is applied to the paper industry.